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Differentiation of Hematopoietic Cells and Leukemia

  

 Thomas Graf

Thomas Graf
 
Hematopoietic stem cells differentiate into more than 10 cell types with different morphologies, antigenic, molecular and functional markers.
In spite of a wealth of research in the field it is not known how a stem cell decides what to become. Here are some of the open questions in which the lab is interested
  • By what pathways and via which intermediate progenitors do the different blood cell types arise?
  • What is the role of transcription factors in blood cell commitment?
  • How flexible are blood cells: does the microenvironment influence the decision making process and can differentiated cells 'change their mind'?
  • What goes wrong in leukemia and can we develop novel tools for therapy?

We are addressing these questions using mice, zebrafish, and human leukemia cell lines as model systems.


Here you can learn about our research!

 
 
 
 
 
 
   
   

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