Gene Targeting Shared Resource

Core Website

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Allows investigators to alter gene function in mice through homologous recombination in embryonic stem (ES) cells followed by germline re-colonization through chimera formation.

 

New Developments @ the Gene Targeting Core

  • Knock-in technology
  • “Cre-lox” system introduced for temporal and spatial gene ablation
  • Bacterial recombination system(recET) introduced for rapid construction of targeting vectors
  • Gridded 129 Bac libraries for efficient gene isolation
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Revised: 03/24/08.

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