Albert Einstein Cancer Center

Selected Achievements

• Macrophages Promote Tumor progression and metastasis
• Macrophage depletion slows tumor progression and inhibits metastasis in mammary cancers
• A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors
• Sensitivity to EGF-1R inhibition by Erlotinib is enhanced in chemo-resistant cells
• CSF-1 signaling as a therapeutic target
• Macrophage motility is a major target of CSF-1 signaling
• Chemotaxis and Cell Migration
• S100A4, a gene over-expressed in metastatic tumors, regulates the actomyosin cytoskeleton
• An invasion gene expression signature defined in breast mammary cancer cells
• WAVE2 is downstream of CSF-1 and involved in macrophage motility
• Spatial regulation of beta-actin translation by ZBP1
• The role of PI 3-Kinase in tumor cell motility and nutrient signaling
• PKC regulates the early barbed-end transient
• The small GTPase Rac proteins regulate tumor cell migration and invasion
• Cofilin at the leading edge
• MRK, a member of the MAPK protein kinase family, regulates cell motility
• ErbB2/ErbB3 heterodimers stimulate tumor cell intravasation and metastasis
• Synuclein Gamma with chaperone activity as an emerging therapeutic target
• Novel PKD isoforms involved in regulating TGF-b ?signaling
• Macrophages are required for mammary development
• Macrophages promote mammary development through the re-modeling of collagen fibers
• Estrogen stimulates epithelial cell proliferation through two independent pathways
• ¹⁸F-fluoro-deoxyglucose as a therapeutic radionuclide in breast cancer
• A new strategy for caging proteins regulated by kinases
• Single-Cell Gene Expression Profiling
• From Silencing to Gene Expression: Real-Time Analysis in Single Cells
• Intravital imaging of tumor cells
• Cell Imaging by Fluorescence in vivo
• Imaging of Gene Expression in Living Cells and Tissues
• Development of Novel Fluorescent Probes