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Contact information:
Margaret Kielian
Department of Cell Biology
Albert Einstein College of Medicine, Room 401, Chanin Building
1300 Morris Park Avenue, Bronx, New York, 10461
Phone (718) 430-3638 Fax (718) 430-8574 email
kielian@aecom.yu.edu
Our lab works on
the entry and exit pathways of enveloped (membrane-coated)
viruses in their host cells. All enveloped viruses use membrane fusion
to infect a cell, and membrane budding to produce new viruses. Studying
these entry and exit processes helps us to understand the mechanisms of
virus infection and to develop new antiviral therapies, and also
provides a key model for cellular membrane fusion and budding reactions.
Our research focuses primarily on alphaviruses and flaviviruses, virus
groups that include important human pathogens such as dengue, West Nile,
and yellow fever viruses.
Graduate students and MD/Ph.D. students are
welcome to join our lab!
You will gain experience in a wide variety
of methods in virology, molecular biology, cell biology, protein
biochemistry (such as selection and analysis of virus mutants, in vitro
mutagenesis, PCR, cloning, cell culture, immunofluorescence, electron microscopy,
pulse-chase analysis, protein expression, purification and analysis,
membrane fusion assays, fluorescence spectroscopy, structural
biology…..).
You will learn about important questions in
virus and cell biology, protein trafficking, protein-membrane
interactions, virus structure and how it controls virus biology…..
Click on the links to learn more about our
research, papers, and training in the Kielian lab.
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