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News
Suzannah Williams, a Postdoc in Dr. Pamela Stanley’s lab has accepted a lecturer’s position in the Department of Physiology, Anatomy and Genetics at the University of Oxford, London. The best of luck, Suzannah!

June 18th, 2007 -- the Department of Cell Biology hosted a one-day symposium honoring the scientific achievements of Dr. Jonathan R. Warner, the Joseph & Gertrud Buchler Chair in Translational Medicine in the Department of Cell Biology and Chairman of the department from 1983 to1998. After the opening remarks by Dean Allen Spiegel and Dr. Arthur Skoultchi, the current Chairman of Cell Biology, a number of distinguished guests reflected on Dr. Warner’s seminal discoveries in the field of ribosomal biogenesis as well as ongoing scientific pursuits in their own laboratories: Dr. James Darnell, Rockefeller University. "Four-plus decades of science and friendship"; Dr. Elaine Elion, Harvard University. "Tailoring mitogen-activated protein kinase cascades for differentiation and survival"; Dr. Alexander Rich, MIT. "The biology of proteins that bind to left-handed Z-DNA"; Dr. Stephen Udem, International AIDS Vaccine Initiative. "Vaccines: so much we now can do but too damned scared to do it!"; Dr. Joan Steitz, Yale University. "Regulatory RNPs: Altering outcomes in gene expression"; Dr. Ke Shuai, UCLA. "Protein SUMO ligases in the regulation of cytokine signaling and immunity"; Dr. Masayasu Nomura, University of California-Irvine School of Medicine. "Transcription of rRNA by RNA polymerase I is functionally coupled to rRNA processing and ribosome assembly". The scientific program concluded with a talk by Dr. Warner entitled “Ribosomes, RNA, and Friends.”

Photo Gallery

May, 2007 --  Michael Papetti, a Postdoc in Dr. Art Skoultchi’s lab and a good friend and colleague to many students and postdocs in this department, will move to his new position as an instructor in the Department of Medicine at Montefiore Hospital. The best of luck, Mike! 

December 15, 2006 - Dr. Yuhong Fan, an Instructor from Dr. Arthur Skoultchi's Lab will soon start at her new position as Assistant Professor of Molecular and Cell Biology at the Georgia Institute of Technology in Atlanta. Let's wish her GOOD LUCK and SUCCESS in her own lab!!

December 18, 2006 - Dr. Margaret Kielian is named a member of the Editorial Board of Cell Host & Microbe, a new journal in the Cell Press family scheduled to be launching in March 2007.
New Ph. D

April 22, 2008 - Lily Wu of Dr. Rick Kitsis' Lab successfully defended her Ph.D. thesis. Our warmest congratulations to Dr. Lily Wu and the Kitsis laboratory.

September 20, 21, 2007 - Ja Young Kim and Zhao Wang of Dr. Philipp Scherer's Lab successfully defended their Ph.D. thesis. Our warmest congratulations to Dr. Ja Young Kim, Dr. Zhao Wang and the Scherer laboratory.


September 17, 2007 - Yingfeng Deng of Dr. Robert Singer's Lab successfully defended her Ph.D. thesis. Our warmest congratulations to Dr. Yingfeng Deng and the Singer laboratory. 


November 6, 2006 - Erhu Cao of Dr. Stanley Nathenson's Lab successfully defended his Ph.D. thesis. Our warmest congratulations to Dr. Erhu Cao and the Nathenson laboratory.


October 27, 2006
-- Lourdes Mendez of Dr. B. Hilda Ye's Lab successfully defended her Ph.D. thesis. Our warmest congratulations to Dr. Lourdes Mendez and the Ye laboratory!”

Awards

December 18, 2007 -- Dr. Charles Query, Associate Professor of Department of Cell Biology, was awarded an "Irma T. Hirschl Career Scientist Award". 

November 5, 2007 -- Dr. Stanley G. Nathenson, Distinguished Professor of Microbiology & Immunology, and of Cell Biology, and Samuel H. Golding Professor of Microbiology, has been selected as the recipient of the second annual Marshall S. Horwitz, M.D. Faculty Prize for Research Excellence. The award ceremony and lecture will take place on Wednesday, January 16, 2008, at 4:00PM in the Robbins Auditorium.

November 1, 2007 -- The Belfer Institute for Advanced Biomedical Studies recently held a competition for the fourth annual Outstanding Postdoctoral Research Scholar Prizes. Dr. Alexander Konev (laboratory of Dr. Dmitry Fyodorov) and Dr. Yong-Zhen Xu (laboratory of Dr. Charles Query) are among the six winners to receive this prize. They will present their award winning work at a ceremony on Monday, December 3, 2007 at 3:00 pm in Robbins Auditorium.

October, 2007 --  Dr. Pamela Stanley was appointed last October as a permanent member of the Intercellular Communications and interactions (ICI) NIH study section.

October 20, 2007 -- Dr. Kerri McIntosh, a Post-doc in Jon Warner's lab, was recently awarded a Postdoctoral Fellowship from NSERC, the Canadian equivalent of the NSF.

Septemner 6, 2007 -- Laura Norwood, a postdoctoral associate in Arthur Skoultchi's lab was recently awarded an NIH fellowship.

May 30, 2007
-- Dr. Michael Keogh, Assistant Professor of Department of Cell Biology, was awarded a "New York Academy of Medicine Speakers Fund for Biomedical Research award".

April 18, 2007 -- Dr. Dmitry Fyodorov, Assistant Professor, received a "Scholar of the Sidney Kimmel Foundation for Cancer Research".

April 11, 2007 -- Dean Allen Spiegel announced several endowed chairs for distinguished AECOM faculty members. Among these, Dr Pamela Stanley is the recipient of a chair established by the Horace Goldsmith Foundation. Dr. Eric Bouhassira will occupy another chair in Stem Cell Biology established by a generous gift from Ira and Ingeborg Rennert. Cheers to both Pamela and Eric!

February 16, 2007 -- Erhu Cao, who recently defended his PhD thesis and is now a postdoctoral associate in Stanley Nathenson's lab, is one of the three recipients of 2007 Julius Marmur Research Awards. He will present his work at the 11th Annual Julius Marmur Symposium on Thursday, March 29, 2007 at 9:30 am.

January 25, 2007 -- Dr. Rick Kitsis, Professor, Departments of Cell Biology and Medicine, is being chosen Chair of the
Council on Basic Cardiovascular Sciences of the American Heart Association.

January 22, 2007 -- Dr. Matthew Scharff, Distinguished Professor of Cell Biology and Medicine, has received the Faculty Mentoring Award for Research Excellence. Awards to be presented by Dean Allen Spiegel at Davidoff Day, Tuesday, January 30, 11:00AM, in the Riklis Auditorium concert hall.

November 8, 2006 –
Dr. Belinda Ding, a Postdoctoral associate in Dr. B. Hilda Ye’s lab, is the recipient of a one year fellowship grant from the Lauri Strauss Leukemia Foundation.

October 16, 2006 --
Dr. Matthew Scharff, professor of cell biology and the Harry Eagle Professor of Cancer Research, has received the first annual Marshall S. Horwitz, M.D. Faculty Prize for Research Excellence. 
He will present his inaugural lecture on Wednesday, November 15, 2006, 4:00PM, in the Robbins Auditorium concert hall.

February 16, 2006
-- Maofu Liao, a graduate student from Dr. Margret Kielian's lab, was selected for the 2006 Julius Marmur Research Award.

Dr. Yuhong Fan, Dr. Ziqiang Li and Dr. Yuxun Wang received the second annual Outstanding Postdoctoral Research Scholar of the Belfer Institute for Advanced Biomedical Studies of year 2005.

September 10,  2005 -- Dr. Stanley G. Nathenson, Samuel H. Golding Chair in Immunology and Professor of Microbiology and Immunology/Cell Biology was recently elected to become an honorary member of the Hungarian Academy of Sciences.

May 2, 2005 -- Dr. Barbara Birshtein received the Harry Eagle Award for Outstanding Basic Science Teaching.

April 7, 2005 -- Dr. Philipp Scherer has been named the 2005 recipient of the Outstanding Scientific Achievement Award of the American Diabetes Association (ADA). The award recognizes research in diabetes that demonstrates particular independence of thought and originality. It is the highest honor given by the association and will be presented on June 13, at the 65th Annual Scientific Sessions of the ADA.

April 5, 2005 -- Utpal Pajvani, an MSTP student who carried out his thesis work in the Scherer lab studying adiponectin, is one of the four recipients of the 2005 Julius Marmur Awards at AECOM.

Christina Medina, a PhD student in Dr. Rick Kitsis' lab, who was recently awarded a Ford Foundation Diversity Fellowship.

October 16, 2003 -- (BRONX, NY) -- Dr. Matthew Scharff, professor of cell biology and the Harry Eagle Professor of Cancer Research at the Albert Einstein College of Medicine of Yeshiva University, has received the City of New York's highest honor for achievement in the biological and medical sciences.
The award, known as the Mayor's Lifetime Achievement Award for Excellence in Biological & Medical Sciences, was presented to Dr. Scharff by Mayor Michael R. Bloomberg at a ceremony held at the Brooklyn Botanical Gardens on Oct. 8.

January 12, 2003 -- Dr. Pamela Stanley received The Karl Meyer Award for Glycoconjugate research and International Glycoconjugate Organization Award.

 
New Faces
On March 3, 2008, Ms. Maria Chevere joins the Cell Biology Office as an Administrative Assistant effective. Maria comes to us from Berkley College.

In February 2006, Dr. Ulrich Steidl joins the Department of Cell Biology as an assistant professor.

On October 30, 2007, Alexis Huffman joins the Department of Cell Biology as our new Facilities Manager.

Ms. Stephanie Velasquez was hired as Administrative Assistant effective April 2, 2007. Stephanie comes to us from the Department of Human Resources.

Ms. Danielle Crane and Ms. Jacqueline DiDomenico will join the administration staff on April 16, 2007. Danielle is our new Assistant Administrator replacing Diana Santanello. 

 
In September 2006, Dr. Michael-Christopher Keogh joins the Department of Cell Biology as an assistant professor.
 
Top Notch Papers
Ge C, Stanley P.
The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development.Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1539-44.

Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G, Ye BH.
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood.2008 Feb 1;111(3):1515-23.

Foo RS, Nam YJ, Ostreicher MJ, Metzl MD, Whelan RS, Peng CF, Ashton AW, Fu W, Mani K, Chin SF, Provenzano E, Ellis I, Figg N, Pinder S, Bennett MR, Caldas C, Kitsis RN.
Regulation of p53 tetramerization and nuclear export by ARC. Proc Natl Acad Sci U S A. 2007 Dec 26;104(52):20826-31.

Xu, Y.-Z. and Query, C.C. (2007). Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Molecular Cell, 838-849.  

Yan Q, Malashkevich VN, Fedorov A, Fedorov E, Cao E, Lary JW, Cole JL, Nathenson SG, Almo SC. Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10583-8.

Ronai D, Iglesias-Ussel MD, Fan M, Li Z, Martin A, Scharff MD. Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. J Exp Med. 2007 Jan 22;204(1):181-90.

Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O. Global chromatin compaction limits the strength of the DNA damage response. J Cell Biol. 2007 Sep 24;178(7):1101-8.


Konev AY, Tribus M, Park SY, Podhraski V, Lim CY, Emelyanov AV, Vershilova E, Pirrotta V, Kadonaga JT, Lusser A, Fyodorov DV.
CHD1 motor protein is required for deposition of histone variant H3.3 into chromatin in vivo.
Science. 2007 Aug 24;317(5841):1087-90.

Liu L, Query CC, Konarska MM.
Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.
Nat Struct Mol Biol. 2007 Jun;14(6):519-26. Epub 2007 May 7.

Cao E, Ramagopal UA, Fedorov A, Fedorov E, Yan Q, Lary JW, Cole JL, Nathenson SG, Almo SC.
NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family.
Immunity. 2006 Oct;25(4):559-70. 

Li Z, Zhao C, Iglesias-Ussel MD, Polonskaya Z, Zhuang M, Yang G, Luo Z, Edelmann W, Scharff MD.
The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.
Immunity. 2006 Apr;24(4):393-403. 

Konarska MM, Vilardell J, Query CC.
Repositioning of the reaction intermediate within the catalytic center of the spliceosome.
Mol Cell. 2006 Feb 17;21(4):543-53.

Fan Y, Nikitina T, Zhao J, Fleury TJ, Bhattacharyya R, Bouhassira EE, Stein A, Woodcock CL, Skoultchi AI.
Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation.
Cell. 2005 Dec 29;123(7):1199-212. 

Huttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH.
Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.
Nature. 2005 Nov 24;438(7067):512-5. 

Norio P, Kosiyatrakul S, Yang Q, Guan Z, Brown NM, Thomas S, Riblet R, Schildkraut CL.
Progressive activation of DNA replication initiation in large domains of the immunoglobulin heavy chain locus during B cell development.
Mol Cell. 2005 Nov 23;20(4):575-87. 

Stopka T, Amanatullah DF, Papetti M, Skoultchi AI.
PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure.
EMBO J. 2005 Nov 2;24(21):3712-23. Epub 2005 Oct 13. 

Liao M, Kielian M.
Domain III from class II fusion proteins functions as a dominant-negative inhibitor of virus membrane fusion.
J Cell Biol. 2005 Oct 10;171(1):111-20. 

Wang Y, Putnam CD, Kane MF, Zhang W, Edelmann L, Russell R, Carrion DV, Chin L, Kucherlapati R, Kolodner RD, Edelmann W.
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice.
Nat Genet. 2005 Jul;37(7):750-5. 

Pajvani UB, Trujillo ME, Combs TP, Iyengar P, Jelicks L, Roth KA, Kitsis RN, Scherer PE.
Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.
Nat Med. 2005 Jul;11(7):797-803. 

Rudra D, Zhao Y, Warner JR.
Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins.
EMBO J. 2005 Feb 9;24(3):533-42.

Gibbons DL, Vaney MC, Roussel A, Vigouroux A, Reilly B, Lepault J, Kielian M, Rey FA.
Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus.
Nature. 2004 Jan 22;427(6972):320-5.