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Syun-Ru Yeh, Ph.D. Associate Professor |
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Syun-Ru Yeh, Ph.D. Associate Professor |
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Protein Folding and Dynamics Structure and Function Relationships in Hemeproteins Laser Spectroscopy Faculty Record Proteins are the building blocks for all life
forms. They are produced in ribosomes as non-structured nascent
polypeptides, which subsequently fold into functional proteins. The first
goal of my research program is to understand the general principle underlies
protein folding reactions. The current interest is to dissect the folding
pathways of cytochrome c, myoglobin and fatty acid binding proteins. The
second goal of my research focuses on the studies of the structure-function
relationships in bacterial hemoglobins, human indoleamine dioxygenase and
bovine cytochrome bc1. In my research program, a wide array of spectroscopic
tools, including optical absorption, fluorescence, circular dichroism and UV
/ VIS resonance Raman scattering, are utilized to study various biological
processes. With the state-of-the-art rapid solution mixing technique
developed in my laboratory along with conventional stopped-flow apparatus
and laser flash photolysis systems, we are able to follow biological
reactions from nanosecond to hours. |