Research Series Activity Codes: R01, R03, R21
(aka "Research Grant Mechanisms")

R01 Research Project
        "To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an
 area representing his/her specific interest and competencies."  R01 guidelines comprise the instructions for the 
PHS 398 form and any additional instructions found in NIH program announcements or requests for applications.  
Funding may be requested for a maximum of 5 years.  All requests for more than $500,000 direct costs in any 
year must be approved prior to application.    Grants are renewable.   There are no citizenship requirements.

How R01s are reviewed

R03 Small Research Grant 
       "To provide research support specifically limited in time and amount for studies in categorical program areas.  
Small grants provide flexibility for initiating studies which are generally for preliminary short-term projects and are 
non-renewable."  R03 guidelines vary between NIH institutes.  Generally, these grants provide a maximum of  
$50,000 direct costs per year for 2 years.  Most R03 applications must be in response to program announcements 
or requests for applications.  Contact NIH institute program directors before preparing R03 applications.

R21 Exploratory/Developmental
        "To encourage the development of new research activities in categorical program areas.  Support generally 
is restricted in level of support and in time."  R21 grants tend to fund research that may not be supported by 
considerable preliminary data.  R21 guidelines vary between NIH institutes.  Generally, these grants provide a 
maximum of   $125,000 direct costs per year for 2 years.  Most R21 applications must be in response to program
announcements or requests for applications.  Contact NIH institute program directors before preparing R21 applications.

How R21s are reviewed

 

                                             
                                               
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This site was last updated  November 24,  2008
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