The 19-month long preclerkship curriculum is devoted primarily to interdisciplinary biomedical science courses taking place in lecture halls, conference rooms and laboratories. There are also courses in which students interact with patients, learn the basics of patient-doctor communication, acquire physical examination and diagnostic skills, study medical ethics, and learn how psychosocial and cultural factors affect patient behavior. Medical Spanish courses are offered in both first and second year as electives.

During the last two years of the curriculum, students learn how to apply biomedical science knowledge and clinical skills to problems of human disease and illness in both inpatient and outpatient settings. The third year consists of clerkships in Internal Medicine, Surgery, Pediatrics, Psychiatry, Obstetrics and Gynecology, Family Medicine, Geriatrics, and Radiology; and the fourth year consists of a required Sub-internship in Medicine or Pediatrics, clerkships in Neurology and Ambulatory Care, and 7 months of electives. Small-group case based conferences dealing with issues of prevention, ethics and professionalism are scheduled throughout the clerkship year.

Many Einstein students devote a fifth year of study, with no extra tuition cost, to projects in research, global health, health policy or public health. Some enroll in MPH programs in schools of public health. Others enroll in programs leading to the MS degree in clinical research methods. Students accepted into any of the foregoing programs are eligible for Einstein fellowships, and they also compete successfully in national fellowship programs such as those sponsored by the Howard Hughes Medical Institute or NIH.

As a requirement for graduation, students prepare a paper of scholarly substance based on a mentor-guided project of at least 6-weeks duration.