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Freundlich, J.S., Anderson, J.W., Sarantakis, D., Shieh, H.M., Yu, M., Valderramos, J.C., Lucumi, E., Kuo, M., Jacobs, W.R. Jr., Fidock, D.a., Schiehser, G.A., Jacobus, D.P., Sacchettini, J.C. (2005) Synthesis, Biological activity, and X-ray Crystal Structural Analysis of Diaryl Either Inhibitors of Malarial Enoyl Acyl Carrier Protein Reductase. Part 1: 4'-Substituted Triclosan Derivatives. Bioorganic & Medicinal Chemistry Letters. 15:5247-5252. Ojha, A., Anand, M., Bhatt, A., Kremer, L., Jacobs, W.R.,Jr. Hatfull, G.F. (2005) GroEL1: A Dedicated Chaperone Involved in Mycolic Acid Biosynthesis during Biofilm formation in Mycobacteria. Cell 123:861-873. Bhatt, A., Kremer, L., Dai, A.Z., Sacchettini, J.C., and Jacobs, W.R.,Jr. (2005) Conditional Depletion of KasA, a Key Enzyme of Mycolic Acid biosynthesis, Leads to Myobacterial Cell Lysis. J. Bacteriol. 187:7596-7606. Colangeli, R., Helb, D., Sridharan, S., Sun, J., Varma-Basil, M., Hazbon, M.H., Hom, D., Harbacheuski, R., Megjugorac, N.J., Jacobs, W.R., Jr., Holzenberg, A., Sacchettini, J.C. and Alland, D. (2005) The Mycobacterium tuberculosis iniA Gene is Essential for Activity of an Efflux Pump that Confers Drug Tolerance to Both Isoniazid and Ethambutol. Mol. Microbiol. 55:1829-1840. Sambandamurthy, V.K., Jacobs, W.R. Jr. (2005) Live attenuated mutants of Mycobacterium tuberculosis as candidate vaccines against tuberculosis. Micro. Infect. 7:955-961. Vilcheze, C., Weisbrod, T.R., Chen, B., Kremer, L., Hazbon, M.H., Wang, F., Alland, D., Sacchettini, J.C., Jacobs, W.R., Jr. (2005) Altered NADH/NAD+ Ratios Mediate Coresistance to Isoniazid and Ethionamide in Mycobacteria. Antimicrobiol. Agents Chem. 49:708-720. Hisert, K.B., Kirksey, M.A., Gomez, J.E. Sousa, A.O., Cox, J.S., Jacobs, W.R., Jr., Nathan, C.F., McKinney, J.D. (2005) Identification of Mycobacterium tuberculosis counterimmune (cim) mutants in immunodeficient mice by differential screening. Infect. Immun. 72:5315-5321. Sambandamurthy V.K., Derrick, S.C., Jalapathy, K.V., Chen, B., Russell, R.G., Morris, S.L. and Jacobs, W.R., Jr. (2005) Long-Term Protection Against Tuberculosis Following Vaccination with a Severely Attenuated Double Lysine and Pantothenate Auxotroph of Mycobacterium tuberculosis. Infec. Immun. 73:1196-1203. |
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